Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensively recently and this review will point you towards some of these excellent papers. My own personal view of the potential importance of DISC1 was echoed in a recent review which suggested that DISC1 may be a ‘Rosetta Stone’ for schizophrenia research [Ross, Margolis, Reading, Pletnikov and Coyle (2006) Neuron 52, 139–153]. Our own efforts to try to understand the function of DISC1 were through identification of its protein-binding partners. Through an extensive Y2H (yeast two-hybrid) and bioinformatics effort we generated the ‘DISC1-Interactome’, a comprehensive network of protein–protein interactions around DISC1. In two excellent industry–academia collaborations we focused on two main interacting partners: Ndel1 (nudE nuclear distribution gene E homologue-like 1), an enigmatic protein which may have diverse functions as both a cysteine protease and a key centrosomal structural protein; and PDE4B, a cAMP-specific phosphodiesterase. I will review the work around these two protein complexes in detail.
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November 2007
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Conference Article|
October 25 2007
Dissecting DISC1 function through protein–protein interactions
N.J. Brandon
N.J. Brandon
1
1Schizophrenia and Bipolar Research, Wyeth Discovery Neuroscience, CN8000, Princeton, NJ 08543, U.S.A.
1email brandon@wyeth.com
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Publisher: Portland Press Ltd
Received:
June 11 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1283–1286.
Article history
Received:
June 11 2007
Citation
N.J. Brandon; Dissecting DISC1 function through protein–protein interactions. Biochem Soc Trans 1 November 2007; 35 (5): 1283–1286. doi: https://doi.org/10.1042/BST0351283
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