Subcellular compartmentalization of PDEs (phosphodiesterases) is a major mechanism for the regulation of cAMP signalling. The identification of the proteins that recruit specific PDE isoforms to subcellular compartments can shed light on the regulation of spatial and temporal cAMP gradients in living cells and provide novel therapeutic targets for inhibiting functions of PDEs. We showed recently that p75NTR (p75 neurotrophin receptor) interacts directly with a single PDE isoform, namely PDE4A4/5, via binding to its unique C-terminal region, and targets cAMP degradation to the membrane. The purpose of this review is to present the biological significance of PDE4A compartmentalization by p75NTR and discuss the potential of inhibiting the interaction between p75NTR and PDE4A for the development of an isoform-specific inhihibitor for PDEs.
Skip Nav Destination
Article navigation
November 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2007
Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors
B.D. Sachs;
B.D. Sachs
1Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-90636, U.S.A.
Search for other works by this author on:
K. Akassoglou
K. Akassoglou
1
1Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-90636, U.S.A.
1To whom correspondence should be addressed (email akass@ucsd.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 07 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1273–1277.
Article history
Received:
August 07 2007
Citation
B.D. Sachs, K. Akassoglou; Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors. Biochem Soc Trans 1 November 2007; 35 (5): 1273–1277. doi: https://doi.org/10.1042/BST0351273
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.