Most neurons in the central nervous system co-express peptides alongside their principal transmitter, yet the function of these peptides is largely unknown. Vasopressin neurons of the hypothalamic supraoptic nucleus and paraventricular nucleus contain among the highest concentrations of dynorphin found in the brain. Dynorphin, an endogenous opioid peptide, is co-localized in the same neurosecretory vesicles as vasopressin and is released alongside vasopressin from the dendrites and axon terminals of vasopressin neurons. We and others have shown that neuropeptide release from the soma and dendrites of vasopressin neurons activates vasopressin receptors and κ-opioid receptors to cause activity-dependent modulation of vasopressin neuron activity, and that this is essential for activity patterning in vasopressin neurons.
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November 2007
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Conference Article|
October 25 2007
Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons
C.H. Brown;
C.H. Brown
*Department of Physiology and Centre for Neuroendocrinology, University of Otago, Dunedin 9054, New Zealand
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V. Scott;
V. Scott
*Department of Physiology and Centre for Neuroendocrinology, University of Otago, Dunedin 9054, New Zealand
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M. Ludwig;
M. Ludwig
†Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, U.K.
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G. Leng;
G. Leng
†Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, U.K.
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C.W. Bourque
C.W. Bourque
1
‡Centre for Research in Neuroscience, McGill University, Montreal, QC, Canada
1To whom correspondence should be addressed (email colin.brown@stonebow.otago.ac.nz).
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Publisher: Portland Press Ltd
Received:
June 11 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1236–1242.
Article history
Received:
June 11 2007
Citation
C.H. Brown, V. Scott, M. Ludwig, G. Leng, C.W. Bourque; Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons. Biochem Soc Trans 1 November 2007; 35 (5): 1236–1242. doi: https://doi.org/10.1042/BST0351236
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