The gastrointestinal tract actively responds to the presence of nutrients in the lumen, and there is a high level of specificity to these responses. This specificity exists for different nutrient types and anatomical regions, with physiologically appropriate target end-organ responses. This review will journey from outlining the effects of dietary fat on digestive function and feeding behaviour to the evidence for lipid sensory cells, particularly the enteroendocrine system, in the epithelium. It will also outline potential molecular bases for these mechanisms. This will deal exclusively with issues specific to fatty acid sensing and not the emergent acid pH-sensing mechanisms that may also be activated in the presence of free fatty acids.
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Conference Article| October 25 2007
Long-chain fatty acid sensing in the gastrointestinal tract
J. McLaughlin 1
1Gastrointestinal Sciences, Faculty of Medical and Human Sciences, Manchester University, Oxford Road, Manchester M13 9PT, U.K., and Gastrointestinal Sciences, Clinical Sciences Building, Hope Hospital, Stott Lane, Salford M6 8HD, U.K.
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J. McLaughlin; Long-chain fatty acid sensing in the gastrointestinal tract. Biochem Soc Trans 1 November 2007; 35 (5): 1199–1202. doi: https://doi.org/10.1042/BST0351199
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