Regulation of reduction/oxidation (redox) state is critical for cell viability, activation, proliferation and organ function, and imbalance of oxidant/antioxidant balance is implicated in various chronic respiratory inflammatory diseases, such as asthma, pulmonary fibrosis and chronic obstructive pulmonary disease. CS (cigarette smoke) is a complex mixture of various noxious gases and condensed tar particles. These components elicit oxidative stress in lungs by continuous generation of ROS (reactive oxygen species) and various inflammatory mediators. In the present review, we have discussed the role of oxidative stress in triggering the inflammatory response in the lungs in response to CS by demonstrating the role of NADPH oxidase, redox-sensitive transcription factors, such as pro-inflammatory NF-κB (nuclear factor κB) and antioxidant Nrf2 (nuclear factor-erythroid 2 p45 subunit-related factor 2), as well as HDAC (histone deacetylase) in pro-inflammatory cytokine release by disruption of HDAC–RelA/p65 NF-κB complex.
Skip Nav Destination
Article navigation
November 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2007
Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling
H. Yao;
H. Yao
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
S.-R. Yang;
S.-R. Yang
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
A. Kode;
A. Kode
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
S. Rajendrasozhan;
S. Rajendrasozhan
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
S. Caito;
S. Caito
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
D. Adenuga;
D. Adenuga
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
R. Henry;
R. Henry
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
I. Edirisinghe;
I. Edirisinghe
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
Search for other works by this author on:
I. Rahman
I. Rahman
1
1Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave., Rochester, NY, U.S.A.
1To whom correspondence should be addressed (email irfan_rahman@urmc.rochester.edu).
Search for other works by this author on:
Biochem Soc Trans (2007) 35 (5): 1151–1155.
Article history
Received:
May 03 2007
Citation
H. Yao, S.-R. Yang, A. Kode, S. Rajendrasozhan, S. Caito, D. Adenuga, R. Henry, I. Edirisinghe, I. Rahman; Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling. Biochem Soc Trans 1 November 2007; 35 (5): 1151–1155. doi: https://doi.org/10.1042/BST0351151
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.