The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110γ. Studies of p110γ-knockout mice have shown an essential function for this isoform in chemotaxis of neutrophils and macrophages both in vitro and in vivo. However, the roles of p110γ and other PI3K enzymes and regulatory subunits in lymphocyte motility have been more difficult to discern. Recent studies of adoptively transferred, fluorescently labelled lymphocytes have revealed complex and unexpected functions for PI3K in lymphocyte migration in vivo. In this review we highlight cell-type-specific roles for PI3K catalytic and regulatory subunits in the homing and basal motility of lymphocytes in the intact lymph node.
Skip Nav Destination
Article navigation
November 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2007
Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase
J.S. Oak;
J.S. Oak
*Center for Immunology, University of California, Irvine, Irvine, CA 92697, U.S.A.
†Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, U.S.A.
Search for other works by this author on:
M.P. Matheu;
M.P. Matheu
*Center for Immunology, University of California, Irvine, Irvine, CA 92697, U.S.A.
‡Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, U.S.A.
Search for other works by this author on:
I. Parker;
I. Parker
‡Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, U.S.A.
§Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, U.S.A.
Search for other works by this author on:
M.D. Cahalan;
M.D. Cahalan
*Center for Immunology, University of California, Irvine, Irvine, CA 92697, U.S.A.
‡Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, U.S.A.
Search for other works by this author on:
D.A. Fruman
D.A. Fruman
1
*Center for Immunology, University of California, Irvine, Irvine, CA 92697, U.S.A.
†Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, U.S.A.
1To whom correspondence should be addressed (email dfruman@uci.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 10 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1109–1113.
Article history
Received:
June 10 2007
Citation
J.S. Oak, M.P. Matheu, I. Parker, M.D. Cahalan, D.A. Fruman; Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase. Biochem Soc Trans 1 November 2007; 35 (5): 1109–1113. doi: https://doi.org/10.1042/BST0351109
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.