Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a central role in necrotic and apoptotic cell death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) ϵ plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCϵ resides at the mitochondria. Proposed mitochondrial targets of PKCϵ include mitoKATP (mitochondrial ATP-sensitive K+ channel), components of the MPTP (mitochondrial permeability transition pore) and components of the electron transport chain. This review highlights mitochondrial targets of PKCϵ and their possible role in cardioprotective signalling in the setting of ischaemia/reperfusion injury.
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November 2007
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Conference Article|
October 25 2007
Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage
G.R. Budas;
G.R. Budas
1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, U.S.A.
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D. Mochly-Rosen
D. Mochly-Rosen
1
1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, U.S.A.
1To whom correspondence should be addressed (email mochly@stanford.edu).
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Publisher: Portland Press Ltd
Received:
June 27 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Article history
Received:
June 27 2007
Citation
G.R. Budas, D. Mochly-Rosen; Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage. Biochem Soc Trans 1 November 2007; 35 (5): 1052–1054. doi: https://doi.org/10.1042/BST0351052
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