Recently, it was found that Bcl-2 family proteins can affect the apoptotic process by modifying Ca2+ released from the ER (endoplasmic reticulum). In this review, we summarize the evidence that Bcl-2 and Bax can modulate Ca2+ mobilization from the ER to the cytosol and mitochondria. We also found evidence that both Bcl-2 and Bax can interact with IP3Rs (InsP3 receptors) to modify the Ca2+ efflux from the ER. On the basis of our findings, we suggest that Bax may interact with IP3Rs to facilitate the release of Ca2+ from the ER during apoptosis.

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