A large body of literature has shown that CPPs (cell-penetrating peptides) are capable of carrying macromolecules across the plasma membrane. CPPs can penetrate a wide variety of tissue types and enable modulation of intracellular targets with molecules that, by themselves, are incapable of penetrating cells. As a result, CPPs are recognized for their potential value in validating intracellular targets that could lead to drug discovery programmes [Dietz and Bahr (2004) Mol. Cell Neurosci. 27, 85–131]. The potential for CPP–drug conjugates to be used as human therapeutic agents has not been extensively explored and there is limited knowledge regarding the characteristics of CPPs which are necessary for drug development. A better understanding of the properties of CPPs relating to in vivo pharmacology, pharmacokinetics, pharmacodynamics and safety will continue to inform and encourage novel drug development efforts using CPPs as therapeutics. Here we will discuss areas of interest for drug development of CPP-conjugated compounds.
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August 2007
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Conference Article|
July 20 2007
Cell-penetrating peptides in drug development: enabling intracellular targets
L. Chen;
L. Chen
1KAI Pharmaceuticals Inc., 270 Littlefield Avenue, South San Francisco, CA 94080, U.S.A.
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S.D. Harrison
S.D. Harrison
1
1KAI Pharmaceuticals Inc., 270 Littlefield Avenue, South San Francisco, CA 94080, U.S.A.
1To whom correspondence should be addressed (email steve.harrison@kaipharma.com).
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Publisher: Portland Press Ltd
Received:
April 23 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (4): 821–825.
Article history
Received:
April 23 2007
Citation
L. Chen, S.D. Harrison; Cell-penetrating peptides in drug development: enabling intracellular targets. Biochem Soc Trans 1 August 2007; 35 (4): 821–825. doi: https://doi.org/10.1042/BST0350821
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