The cytoskeleton, which in most cell types, including the intervertebral disc described here, comprises microfilaments, microtubules and intermediate filaments, plays important functions in many fundamental cellular events, including cell division, motility, protein trafficking and secretion. The cytoskeleton is also critical for communication; for example, alterations to the architecture of the F-actin (filamentous actin) cytoskeletal networks can affect communication between the cells and the extracellular matrix, potentially compromising tissue homoeostasis. Although there are limited studies to date, this paper aims to review current knowledge on F-actin cytoskeletal element organization in intervertebral disc cells, how F-actin differs with pathology and its implications for mechanotransduction.
Skip Nav Destination
Article navigation
August 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 20 2007
F-actin cytoskeletal organization in intervertebral disc health and disease
S. Li;
S. Li
1Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff CF10 3US, U.K.
Search for other works by this author on:
V.C. Duance;
V.C. Duance
1
1Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff CF10 3US, U.K.
1To whom correspondence should be addressed (email duance@cardiff.ac.uk).
Search for other works by this author on:
E.J. Blain
E.J. Blain
1Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff CF10 3US, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 30 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (4): 683–685.
Article history
Received:
March 30 2007
Citation
S. Li, V.C. Duance, E.J. Blain; F-actin cytoskeletal organization in intervertebral disc health and disease. Biochem Soc Trans 1 August 2007; 35 (4): 683–685. doi: https://doi.org/10.1042/BST0350683
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.