SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase-1], an inositol 5-phosphatase expressed in haemopoietic cells, acts by hydrolysing the 5-phosphates from PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathway. SHIP1 plays a major role in inhibiting proliferation of myeloid cells. As a result, SHIP1−/− mice have an increased number of neutrophils and monocytes/macrophages due to enhanced survival and proliferation of their progenitors. Although SHIP1 contributes to PtdIns(3,4,5)P3 metabolism in T-lymphocytes, its exact role in this cell type is much less explored. Jurkat cells have recently emerged as an interesting tool to study SHIP1 function in T-cells because they do not express SHIP1 at the protein level, thereby allowing reintroduction experiments in a relatively easy-to-use system. Data obtained from SHIP1 reintroduction have revealed that SHIP1 not only acts as a negative player in T-cell lines proliferation, but also regulates critical pathways, such as NF-κB (nuclear factor κB) activation, and also appears to remarkably inhibit T-cell apoptosis. On the other hand, experiments using primary T-cells from SHIP1−/− mice have highlighted a new role for SHIP1 in regulatory T-cell development, but also emphasize that this protein is not required for T-cell proliferation. In support of these results, SHIP1−/− mice are lymphopenic, suggesting that SHIP1 function in T-cells differs from its role in the myeloid lineage.
Skip Nav Destination
Article navigation
April 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
March 20 2007
The role of SHIP1 in T-lymphocyte life and death
G. Gloire;
G. Gloire
1
*GIGA, Virology and Immunology Unit, B34, University of Liège, 4000 Liège, Belgium
1To whom correspondence should be addressed (email geoffrey.gloire@ulg.ac.be).
Search for other works by this author on:
C. Erneux;
C. Erneux
†IRIBHM (Interdisciplinary Research Institute), University of Brussels, 1070 Brussels, Belgium
Search for other works by this author on:
J. Piette
J. Piette
*GIGA, Virology and Immunology Unit, B34, University of Liège, 4000 Liège, Belgium
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 09 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 277–280.
Article history
Received:
September 09 2006
Citation
G. Gloire, C. Erneux, J. Piette; The role of SHIP1 in T-lymphocyte life and death. Biochem Soc Trans 1 April 2007; 35 (2): 277–280. doi: https://doi.org/10.1042/BST0350277
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.