Inflammation is a beneficial response to insult or injury which plays an important role in orchestrating the adaptive immune response. The resolution of acute inflammation is an active process that involves the release of anti-inflammatory mediators and the termination of pro-inflammatory signalling pathways coincident with leucocyte apoptosis and phagocytic clearance and the migration of antigen-presenting cells from the site of inflammation to the local lymphatic tissue. The latter process is required for the development of adaptive immunity and immunological memory. The NF-κB (nuclear factor κB) pathway is an important regulator of inflammation and immunity; NF-κB activation is controlled by IKK [IκB (inhibitor of NF-κB) kinase] complex, which regulates NF-κB activation in response to pro-inflammatory stimuli. The IKK complex has two catalytic subunits, IKKα and IKKβ; recent research shows that these highly homologous kinases have distinct roles in inflammation and adaptive immunity. Here, we discuss the emerging roles for IKKα in the tight regulation of inflammation and the development of adaptive immune responses.
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April 2007
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Conference Article|
March 20 2007
IKKα in the regulation of inflammation and adaptive immunity
T. Lawrence;
T. Lawrence
1
1Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, U.K.
1To whom correspondence should be addressed (email t.lawrence@imperial.ac.uk).
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M. Bebien
M. Bebien
1Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, U.K.
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Publisher: Portland Press Ltd
Received:
November 01 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 270–272.
Article history
Received:
November 01 2006
Citation
T. Lawrence, M. Bebien; IKKα in the regulation of inflammation and adaptive immunity. Biochem Soc Trans 1 April 2007; 35 (2): 270–272. doi: https://doi.org/10.1042/BST0350270
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