Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P3 and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCγ isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCγ activity through the interaction of PI3K product PtdIns(3,4,5)P3 and the PLCγ PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway.

Keywords:
growth factor, phospholipase C (PLC), pleckstrin homology domain (PH domain), phosphoinositide 3-kinase (PI3K), Src homology 2 domain (SH2 domain), tyrosine phosphorylation
© 2007 The Biochemical Society
2007
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