The PI3K (phosphoinositide 3-kinase)/Akt (also called protein kinase B) signalling cassette plays a central role in the response to growth factors, particularly insulin-like molecules, and its misregulation is a characteristic feature of diabetes and many forms of human cancer. Recent molecular genetic studies initiated in the fruitfly, Drosophila melanogaster, have highlighted two new cell-type-specific mechanisms regulating PI3K/Akt signalling and its downstream effects. First, the cellular response to this cassette is modulated by several classes of cell-surface transporters and sensors, suggesting an important role for extracellular nutrients in insulin-sensitivity. Secondly, various cell types show a markedly different subcellular distribution of the activated kinase Akt, influencing the cellular functions of this molecule. These findings reveal new mechanisms by which processes such as growth, lipogenesis and insulin resistance can be differentially regulated and may suggest novel strategies for treating insulin-linked diseases.
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April 2007
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Conference Article|
March 20 2007
Extracellular and subcellular regulation of the PI3K/Akt cassette: new mechanisms for controlling insulin and growth factor signalling
C. Wilson;
C. Wilson
1
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
1To whom correspondence should be addressed (email clive.wilson@dpag.ox.ac.uk).
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N. Vereshchagina;
N. Vereshchagina
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
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B. Reynolds;
B. Reynolds
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
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D. Meredith;
D. Meredith
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
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C.A.R. Boyd;
C.A.R. Boyd
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
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D.C.I. Goberdhan
D.C.I. Goberdhan
1Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
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Publisher: Portland Press Ltd
Received:
November 05 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 219–221.
Article history
Received:
November 05 2006
Citation
C. Wilson, N. Vereshchagina, B. Reynolds, D. Meredith, C.A.R. Boyd, D.C.I. Goberdhan; Extracellular and subcellular regulation of the PI3K/Akt cassette: new mechanisms for controlling insulin and growth factor signalling. Biochem Soc Trans 1 April 2007; 35 (2): 219–221. doi: https://doi.org/10.1042/BST0350219
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