The co-ordinated and directional trafficking of T-lymphocytes in lymphoid and peripheral tissues is an important process in lymphoid development, immunosurveillance and immune responses. Members of the chemokine superfamily play a key role in providing navigational cues for T-cells and chemokine receptors couple with a wide range of biochemical signals including phosphoinositide lipid metabolism, elevation of intracellular calcium levels, activation of a wide array of protein kinases as well as small GTPases. One of the most robust biochemical signals elicited by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present paper.
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Conference Article|
March 20 2007
T-lymphocyte navigation and migration: beyond the PI3K paradigm
L. Smith;
L. Smith
1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
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A. Webb;
A. Webb
1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
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S.G. Ward
S.G. Ward
1
1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
1To whom correspondence should be addressed (email S.G.Ward@bath.ac.uk).
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Publisher: Portland Press Ltd
Received:
November 20 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 193–198.
Article history
Received:
November 20 2006
Citation
L. Smith, A. Webb, S.G. Ward; T-lymphocyte navigation and migration: beyond the PI3K paradigm. Biochem Soc Trans 1 April 2007; 35 (2): 193–198. doi: https://doi.org/10.1042/BST0350193
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