The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell–cell interactions. In the central nervous system, matrix adhesion receptors are expressed in the microvasculature and by neurons and their supporting glial cells. Cells within cerebral microvessels express both the integrin and dystroglycan families of matrix adhesion receptors. However, the functional significance of these receptors is only now being explored. Endothelial cells and astrocytes within cerebral capillaries co-operate to generate and maintain the basal lamina and the unique barrier functions of the endothelium. Integrins and the dystroglycan complex are found on the matrix-proximate faces of both endothelial cells and astrocyte end-feet. Pericytes rest against the basal lamina. In the extravascular compartment, select integrins are expressed on neurons, microglial cells and oligodendroglia. Significant alterations in both cellular adhesion receptors and their matrix ligands occur during focal cerebral ischaemia, which support their functional significance in the normal state. We propose that matrix adhesion receptors are essential for the maintenance of the integrity of the blood–brain permeability barrier and that modulation of these receptors contributes to alterations in the barrier during brain injury.
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December 2006
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Conference Article|
October 25 2006
Vascular matrix adhesion and the blood–brain barrier
G.J. del Zoppo;
G.J. del Zoppo
1
*Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U.S.A.
1To whom correspondence should be addressed (email grgdlzop@scripps.edu).
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R. Milner;
R. Milner
*Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U.S.A.
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T. Mabuchi;
T. Mabuchi
†Department of Internal Medicine, Hojyo Tanaka Hospital, Kasai, Japan
‡Division of Strokology, Department of Cardiovascular Medicine, Osaka University Graduate School, Osaka, Japan
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S. Hung;
S. Hung
*Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U.S.A.
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X. Wang;
X. Wang
*Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U.S.A.
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J.A. Koziol
J.A. Koziol
*Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U.S.A.
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Publisher: Portland Press Ltd
Received:
August 11 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1261–1266.
Article history
Received:
August 11 2006
Citation
G.J. del Zoppo, R. Milner, T. Mabuchi, S. Hung, X. Wang, J.A. Koziol; Vascular matrix adhesion and the blood–brain barrier. Biochem Soc Trans 1 December 2006; 34 (6): 1261–1266. doi: https://doi.org/10.1042/BST0341261
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