The biosynthesis of camalexin, the main phytoalexin of the model plant Arabidopsis thaliana, involves at least two CYP (cytochrome P450) steps. It is synthesized from tryptophan via indole-3-acetaldoxime in a reaction catalysed by CYP79B2 and CYP79B3. Based on the pad3 mutant phenotype, CYP71B15 (PAD3) had also been suggested as a camalexin biosynthetic gene. CYP71B15 catalyses the final step in camalexin biosynthesis, as recombinant CYP71B15 and microsomes from Arabidopsis leaves expressing functional PAD3 converted dihydrocamalexic acid into camalexin. The biosynthetic pathway is co-ordinately induced, strictly localized to the site of pathogen infection. This provides a model system to study the regulation of CYP enzymes involved in phytoalexin biosynthesis.
Skip Nav Destination
Article navigation
December 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2006
The role of cytochrome P450 enzymes in the biosynthesis of camalexin
E. Glawischnig
E. Glawischnig
1
1Lehrstuhl für Genetik, Technische Universität München, Am Hochanger 8, 85350 Freising, Germany
1email egl@wzw.tum.de
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 23 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1206–1208.
Article history
Received:
June 23 2006
Citation
E. Glawischnig; The role of cytochrome P450 enzymes in the biosynthesis of camalexin. Biochem Soc Trans 1 December 2006; 34 (6): 1206–1208. doi: https://doi.org/10.1042/BST0341206
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.