Sterols are isoprenoid-derived lipids that are produced via the mevalonate pathway and are involved in various cellular functions in eukaryotes such as maintenance of membrane integrity and biosynthetic precursors of steroid hormones. Among cellular sterols, Δ22-sterols containing a double bond at C-22 in the sterol side chain specifically occur in fungi (ergosterol) and plants (stigmasterol and brassicasterol), and several lines of experimental evidence have suggested specific physiological roles of Δ22-sterols in plants. Fungal cytochrome P450 (P450), CYP61, has been established as the sterol C-22 desaturase functioning at the penultimate step in the ergosterol biosynthetic pathway. On the other hand, no particular sequence has been assigned as to the enzyme responsible for the introduction of the double bond into the sterol side chain in plants. In this review, we summarize our recent findings demonstrating that CYP710A P450 family genes encode the plant sterol C-22 desaturases to produce stigmasterol and brassicasterol/crinosterol from β-sitosterol and 24-epi-campesterol respectively.
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December 2006
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Conference Article|
October 25 2006
Cytochrome P450 subfamily CYP710A genes encode sterol C-22 desaturase in plants
T. Morikawa;
T. Morikawa
*Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599–8531, Japan
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M. Mizutani;
M. Mizutani
†Institute for Chemical Research, Kyoto University, 611–0011 Kyoto, Japan
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D. Ohta
D. Ohta
1
*Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599–8531, Japan
1To whom correspondence should be addressed (email ohtad@bioinfo.osakafu-u.ac.jp).
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Publisher: Portland Press Ltd
Received:
June 21 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1202–1205.
Article history
Received:
June 21 2006
Citation
T. Morikawa, M. Mizutani, D. Ohta; Cytochrome P450 subfamily CYP710A genes encode sterol C-22 desaturase in plants. Biochem Soc Trans 1 December 2006; 34 (6): 1202–1205. doi: https://doi.org/10.1042/BST0341202
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