CYP (cytochrome P450) biodiversity and biotechnology is of importance given the industrial applications and potential for the huge array of genes and proteins that can constitute up to 1% of a coding genome. Historical biotechnological roles for CYPs in mutant fungi diverting the flux of metabolites towards penicillin production, in biotransformations allowing the production of corticosteroids and CYPs as drug targets contribute to interest in the roles of orphan CYPs in the emerging genomes. This area includes studies related to biotransformations and bioremediation, natural product synthesis and its manipulation, tools for exploiting CYPs and using CYPs as biomarkers and drug targets. Fundamental studies on diverse structure and function, on the ecological and evolution of CYPs through geological time and in drug/pesticide resistance also contribute distinctively to this field of CYP research.
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December 2006
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Conference Article|
October 25 2006
Cytochrome P450 biodiversity and biotechnology
S.L. Kelly;
S.L. Kelly
1Institute of Life Science and School of Medicine, Swansea University, Swansea SA2 8PP, Wales, U.K.
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D.C. Lamb;
D.C. Lamb
1Institute of Life Science and School of Medicine, Swansea University, Swansea SA2 8PP, Wales, U.K.
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D.E. Kelly
D.E. Kelly
1
1Institute of Life Science and School of Medicine, Swansea University, Swansea SA2 8PP, Wales, U.K.
1To whom correspondence should be addressed (email D.Kelly@swansea.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 08 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1159–1160.
Article history
Received:
August 08 2006
Citation
S.L. Kelly, D.C. Lamb, D.E. Kelly; Cytochrome P450 biodiversity and biotechnology. Biochem Soc Trans 1 December 2006; 34 (6): 1159–1160. doi: https://doi.org/10.1042/BST0341159
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