The general transcription factor TFIIB (transcription factor IIB) plays a critical role in the assembly of the RNA polymerase II pre-initiation complex. TFIIB can make sequence-specific DNA contacts both upstream and downstream of the TATA box. This has led to the definition of two core promoter BREs (TFIIB-recognition elements), one upstream [BREu (upstream BRE)] and one downstream of TATA box [BREd (downstream BRE)]. TFIIB–BREu and TFIIB–BREd contacts are mediated by two independent DNA-recognition motifs within the core domain of TFIIB. Both the BREu and the BREd modulate the transcriptional potency of a promoter. However, the net effect of the BREs on promoter activity is dependent on the specific blend of elements present within a core promoter.
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December 2006
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Conference Article|
October 25 2006
Core promoter elements recognized by transcription factor IIB
W. Deng;
W. Deng
1Faculty of Life Sciences, The Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
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S.G.E. Roberts
S.G.E. Roberts
1
1Faculty of Life Sciences, The Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (email stefan.roberts@manchester.ac.uk)
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Publisher: Portland Press Ltd
Received:
July 21 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1051–1053.
Article history
Received:
July 21 2006
Citation
W. Deng, S.G.E. Roberts; Core promoter elements recognized by transcription factor IIB. Biochem Soc Trans 1 December 2006; 34 (6): 1051–1053. doi: https://doi.org/10.1042/BST0341051
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