In this mini-review, we provide an overview of those PTPs (protein tyrosine phosphatases) that are relevant to the immune response, highlighting the function of a number of intracellular and transmembrane PTPs that have been identified as having important negative regulatory roles on distinct aspects of host immunity.

Keywords:
autoimmune disease, CD45, Lyp, protein tyrosine phosphatase, Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), T-cell receptor (TCR)
© 2006 The Biochemical Society
2006
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