Inflammatory cascades are initiated in response to alarm signals that may result from infection, malignant transformation or trauma. Immunity, however, must be controlled; otherwise damage may occur to otherwise healthy tissue within the same microenvironment. Similarly, peripheral tolerance mechanisms must ensure that autoreactive thymic or bone marrow emigrants do not respond upon encounter with the autoantigen. Organized lymphoid structures such as lymph nodes, spleen and Peyer's patches appear to regulate inflammation successfully, displaying controlled expansion and contraction. However, when immune cells flood into effector sites, the organization of T- and B-lymphocytes is lacking. What controls inflammatory cascades in lymph nodes but rarely in effector sites is not clear. We believe the difference lies in the Toll-like receptor ligand load, which is high in effector sites and drives uncontrolled inflammation. Similarly, we believe that initiation of autoimmune inflammation is initiated by the liberation of inflammatory signals due to infection or trauma. In this review, we highlight some of the molecules responsible for maintaining an activated T-cell phenotype, strategies to interrupt these therapeutically and the impact of ligating inhibitory receptors on antigen-presenting cells.
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December 2006
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Conference Article|
October 25 2006
The therapeutic potential of positive and negative immune cell co-stimulation during inflammation
E. Gwyer;
E. Gwyer
1Kennedy Institute for Rheumatology, Imperial College London, 1, Aspenlea Road, London W6 8LH, U.K.
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R. Snelgrove;
R. Snelgrove
1Kennedy Institute for Rheumatology, Imperial College London, 1, Aspenlea Road, London W6 8LH, U.K.
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T. Hussell
T. Hussell
1
1Kennedy Institute for Rheumatology, Imperial College London, 1, Aspenlea Road, London W6 8LH, U.K.
1To whom correspondence should be addressed (email t.hussell@imperial.ac.uk)
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Publisher: Portland Press Ltd
Received:
June 27 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1032–1036.
Article history
Received:
June 27 2006
Citation
E. Gwyer, R. Snelgrove, T. Hussell; The therapeutic potential of positive and negative immune cell co-stimulation during inflammation. Biochem Soc Trans 1 December 2006; 34 (6): 1032–1036. doi: https://doi.org/10.1042/BST0341032
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