NAADP (nicotinic acid–adenine dinucleotide phosphate) is a recently described Ca2+-mobilizing molecule. First characterized in the sea urchin egg, it has been shown to mobilize Ca2+ from intracellular stores in a wide range of cells from different organisms. It is a remarkably potent molecule, and recent reports show that its cellular levels change in response to a variety of agonists, confirming its role as a Ca2+-mobilizing messenger. In many cases, NAADP appears to interact with other Ca2+-mobilizing messengers such as IP3 (inositol 1,4,5-trisphosphate) and cADP-ribose in shaping cytosolic Ca2+ signals. What is not clear is the molecular nature of the NAADP-sensitive Ca2+ release mechanism and its subcellular localization. This review focuses on the recent progress made in sea urchin eggs, which indicates that NAADP activates a novel Ca2+ release channel distinct from the relatively well-characterized IP3 and ryanodine receptors. Furthermore, in the sea urchin egg, the NAADP-sensitive store appears to be separate from the endoplasmic reticulum and is most likely an acidic store. These findings have also been reinforced by similar findings in mammalian cells, and a unified model for NAADP-induced Ca2+ signalling is presented.
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Conference Article|
October 25 2006
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores
A. Galione
A. Galione
1
1Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.
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Publisher: Portland Press Ltd
Received:
August 03 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (5): 922–926.
Article history
Received:
August 03 2006
Citation
A. Galione; NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem Soc Trans 1 October 2006; 34 (5): 922–926. doi: https://doi.org/10.1042/BST0340922
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