IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch–clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional IP3Rs in its plasma membrane. Only approx. 50% of the Ca2+ entry evoked by stimulation of the B-cell receptor is mediated by store-operated Ca2+ entry, the remainder appears to be carried by the IP3Rs expressed in the plasma membrane. Ca2+ entering the cell via just two large-conductance IP3Rs is likely to have very different functional consequences from the comparable amount of Ca2+ that enters through the several thousand low-conductance store-operated channels.
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October 2006
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Conference Article|
October 25 2006
Plasma membrane IP3 receptors
C.W. Taylor;
C.W. Taylor
1
1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
1To whom correspondence should be addressed (email cwt1000@cam.ac.uk).
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O. Dellis
O. Dellis
1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
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Biochem Soc Trans (2006) 34 (5): 910–912.
Article history
Received:
June 19 2006
Citation
C.W. Taylor, O. Dellis; Plasma membrane IP3 receptors. Biochem Soc Trans 1 October 2006; 34 (5): 910–912. doi: https://doi.org/10.1042/BST0340910
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