Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the lysosome. We have characterized two de-ubiquitinating enzymes that interact with components of this machinery. AMSH [associated molecule with the SH3 domain (Src homology 3 domain) of STAM (signal transducing adapter molecule)] shows specificity for Lys63- over Lys48-linked ubiquitin and may act to rescue receptors from taking the lysosomal pathway. In contrast, UBPY (ubiquitin-specific processing protease Y) does not discriminate between Lys48 and Lys63-linked chains and is required for lysosomal sorting.
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Conference Article|
October 25 2006
Control of growth factor receptor dynamics by reversible ubiquitination
S. Urbé;
S. Urbé
1
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
1To whom correspondence should be addressed (email urbe@liverpool.ac.uk).
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J. McCullough;
J. McCullough
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
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P. Row;
P. Row
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
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I.A. Prior;
I.A. Prior
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
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R. Welchman;
R. Welchman
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
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M.J. Clague
M.J. Clague
1Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, U.K.
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Publisher: Portland Press Ltd
Received:
June 14 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (5): 754–756.
Article history
Received:
June 14 2006
Citation
S. Urbé, J. McCullough, P. Row, I.A. Prior, R. Welchman, M.J. Clague; Control of growth factor receptor dynamics by reversible ubiquitination. Biochem Soc Trans 1 October 2006; 34 (5): 754–756. doi: https://doi.org/10.1042/BST0340754
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