Assembly and disassembly of the mitotic spindle are essential for both chromosome segregation and cell division. The small G-protein Ran has emerged as an important regulator of spindle assembly. In this review, we look at the role of Ran in different aspects of spindle assembly, including its effects on microtubule assembly dynamics and microtubule organization. In addition, we examine the possibility of a spindle matrix and the role Ran might play in such a structure.
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Conference Article| October 25 2006
Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond
Y. Zheng 1
*Department of Embryology and Department of Biology, Carnegie Institution of Washington, Johns Hopkins University, Baltimore, MD 21218, U.S.A.
†Howard Hughes Medical Institute, Baltimore, MD 21218, U.S.A.
1To whom correspondence should be addressed (email Zheng@ciwemb.edu).
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Publisher: Portland Press Ltd
Received: July 25 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
B. Goodman, Y. Zheng; Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond. Biochem Soc Trans 1 October 2006; 34 (5): 716–721. doi: https://doi.org/10.1042/BST0340716
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