The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic spindles with respect to chromosomes. In addition to this role of soluble Ran-GTP, Ran has two important but less understood roles at mitotic kinetochores. Namely, it is essential for regulation of the spindle assembly checkpoint and for assembly of microtubule fibres that attach kinetochores to spindle poles. Here, I will briefly summarize evidence for these kinetochore-associated functions and mention some of the issues that remain to be addressed regarding them.
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Conference Article|
October 25 2006
Ran at kinetochores
M. Dasso
M. Dasso
1
1Laboratory of Gene Regulation and Development, NICHD (National Institute of Child Health and Human Development)/NIH (National Institutes of Health), Bethesda, MD 20892-5431, U.S.A.
1email mdasso@helix.nih.gov
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Publisher: Portland Press Ltd
Received:
June 27 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (5): 711–715.
Article history
Received:
June 27 2006
Citation
M. Dasso; Ran at kinetochores. Biochem Soc Trans 1 October 2006; 34 (5): 711–715. doi: https://doi.org/10.1042/BST0340711
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