The last decade has witnessed spectacular progress in the identification of the protein apparatus required for exocytosis of neurotransmitters, peptide hormones and other bioactive products. In striking contrast, our knowledge of the mechanisms determining the expression of the components of the secretory machinery has remained rudimentary. Since modifications in secretory functions are associated with several physiological processes and contribute to the development of human pathologies, a better knowledge of the control of the expression of the genes involved in exocytosis is urgently needed. Recent studies have led to the identification of transcription factors and other regulatory molecules such as microRNAs that modulate the cellular level of key controllers of the exocytotic process. These findings furnish a new perspective for understanding how secretory functions can adapt to normal physiological conditions and shed light on the mechanisms involved in the development of important human diseases such as diabetes mellitus characterized by defective release of bioactive compounds.
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October 2006
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Conference Article|
October 25 2006
Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions
A. Abderrahmani;
A. Abderrahmani
*Department of Internal Medicine, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
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V. Plaisance;
V. Plaisance
†Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
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P. Lovis;
P. Lovis
†Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
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R. Regazzi
R. Regazzi
1
†Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
1To whom correspondence should be addressed (email Romano.Regazzi@unil.ch).
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Publisher: Portland Press Ltd
Received:
June 16 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (5): 696–700.
Article history
Received:
June 16 2006
Citation
A. Abderrahmani, V. Plaisance, P. Lovis, R. Regazzi; Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions. Biochem Soc Trans 1 October 2006; 34 (5): 696–700. doi: https://doi.org/10.1042/BST0340696
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