Adaptor or scaffolding proteins are at the basis of multiprotein complexes that spatially and temporally co-ordinate the propagation and integration of a broad range of cellular events. One class of scaffolding proteins are AKAPs (A-kinase-anchoring proteins). They sequester PKA (protein kinase A) and other signalling molecules including phosphodiesterases, other protein kinases and protein phosphatases to specific subcellular compartments. AKAP-dependent protein–protein interactions play a role in many physiologically relevant processes. For example, AKAP–PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or β-adrenoceptor-induced increases in cardiac myocyte contractility. Here, we discuss recently developed peptide disruptors of AKAP–PKA interactions. Such peptides are valuable tools to study the relevance of PKA anchoring in cellular processes.
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August 2006
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Conference Article|
July 21 2006
Peptides for disruption of PKA anchoring
C. Hundsrucker;
C. Hundsrucker
*Leibniz-Institut für Molekulare Pharmakologie, Campus Berlin-Buch, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany
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W. Rosenthal;
W. Rosenthal
*Leibniz-Institut für Molekulare Pharmakologie, Campus Berlin-Buch, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany
†Institut für Pharmakologie, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Campus Benjamin Franklin, Thielallee 67-73, 14195 Berlin, Germany
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E. Klussmann
E. Klussmann
1
*Leibniz-Institut für Molekulare Pharmakologie, Campus Berlin-Buch, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany
†Institut für Pharmakologie, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Campus Benjamin Franklin, Thielallee 67-73, 14195 Berlin, Germany
1To whom correspondence should be addressed (email klussmann@fmp-berlin.de).
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Publisher: Portland Press Ltd
Received:
April 06 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (4): 472–473.
Article history
Received:
April 06 2006
Citation
C. Hundsrucker, W. Rosenthal, E. Klussmann; Peptides for disruption of PKA anchoring. Biochem Soc Trans 1 August 2006; 34 (4): 472–473. doi: https://doi.org/10.1042/BST0340472
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