EDEN (embryo deadenylation element)-dependent deadenylation is a regulatory process that was initially identified in Xenopus laevis early embryos and was subsequently shown to exist in Drosophila oocytes. Recent data showed that this regulatory process is required for somitic segmentation in Xenopus. Inactivation of EDEN-BP (EDEN-binding protein) causes severe segmentation defects, and the expression of segmentation markers in the Notch signalling pathway is disrupted. We showed that the mRNA encoding XSu(H) (Xenopus suppressor of hairless), a protein central to the Notch pathway, is regulated by EDEN-BP. Our data also indicate that other segmentation RNAs are targets for EDEN-BP. To identify new EDEN-BP targets, a microarray analysis has been undertaken.
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October 2005
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Conference Article|
October 26 2005
Post-transcriptional regulation in Xenopus embryos: role and targets of EDEN-BP
H.B. Osborne;
H.B. Osborne
1
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
1To whom correspondence should be addressed, at UMR 6061, Faculté de Médecine, Université de Rennes 1, 2 avenue du Professeur Léon Bernard, CS 34317, 34043 Rennes cedex, France (email beverley.osborne@univ-rennes1.fr).
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C. Gautier-Courteille;
C. Gautier-Courteille
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
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A. Graindorge;
A. Graindorge
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
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C. Barreau;
C. Barreau
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
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Y. Audic;
Y. Audic
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
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R. Thuret;
R. Thuret
†CNRS UMR 8080, Université Paris Sud, Orsay, France
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N. Pollet;
N. Pollet
†CNRS UMR 8080, Université Paris Sud, Orsay, France
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L. Paillard
L. Paillard
*CNRS UMR 6061, IFR 140, Université de Rennes 1, Rennes, France
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Biochem Soc Trans (2005) 33 (6): 1541–1543.
Article history
Received:
June 17 2005
Citation
H.B. Osborne, C. Gautier-Courteille, A. Graindorge, C. Barreau, Y. Audic, R. Thuret, N. Pollet, L. Paillard; Post-transcriptional regulation in Xenopus embryos: role and targets of EDEN-BP. Biochem Soc Trans 26 October 2005; 33 (6): 1541–1543. doi: https://doi.org/10.1042/BST0331541
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