Centaurin β4 proteins are products of the DDEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arfs (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin β4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Arf, lipid and protein phosphorylation signalling pathways.

Keywords:
ADP-ribosylation factor-GTPase-activating protein (Arf-GAP), Arf-GAP containing Src homology domain, ankyrin repeats, pleckstrin homology domains 1 (ASAP1), cancer, centaurin β4, development and differentiation-enhancing factor 1 (DDEF1), metastasis
© 2005 The Biochemical Society
2005
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