The anti-inflammatory effects of the prototypical second messenger cAMP have been extensively documented in multiple cell types. However, in many instances, the molecular mechanisms by which cAMP elevation disrupts specific pro-inflammatory signalling cascades are unknown. In this review, we will describe the importance of the JAK–STAT (where JAK stands for Janus kinase and STAT for signal transducer and activator of transcription) signalling pathway in vascular endothelial cell function, outline key inhibitory processes that serve to reduce cytokine-stimulated tyrosine phosphorylation and activation of STAT proteins, and discuss possible mechanisms by which intracellular cAMP sensors could interact with these inhibitory processes to diminish cytokine receptor-mediated pro-inflammatory signalling.
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October 2005
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Conference Article|
October 26 2005
Inhibition of pro-inflammatory cytokine receptor signalling by cAMP in vascular endothelial cells
W.A. Sands;
W.A. Sands
1Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
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T.M. Palmer
T.M. Palmer
1
1Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
1To whom correspondence should be addressed (email T.Palmer@bio.gla.ac.uk).
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Biochem Soc Trans (2005) 33 (5): 1126–1128.
Article history
Received:
July 26 2005
Citation
W.A. Sands, T.M. Palmer; Inhibition of pro-inflammatory cytokine receptor signalling by cAMP in vascular endothelial cells. Biochem Soc Trans 26 October 2005; 33 (5): 1126–1128. doi: https://doi.org/10.1042/BST0331126
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