Our research has concentrated upon the protein lipid modification of BACE [β-site amyloid precursor protein cleaving enzyme (β-secretase)], of which very little is currently known. Lipidation influences the production of Aβ (amyloid β-protein) by promoting the dimerization of BACE.

Keywords:
amyloid-β, β-site amyloid precursor protein clearing enzyme (BACE), cerulenin, dimer, farnesylation, palmitoylation
© 2005 The Biochemical Society
2005
You do not currently have access to this content.