P450s (cytochrome P450 mono-oxygenases) are a superfamily of haem-containing mono-oxygenase enzymes that participate in a wide range of biochemical pathways in different organisms from all of the domains of life. To facilitate their activity, P450s require sequential delivery of two electrons passed from one or more redox partner enzymes. Although the P450 enzymes themselves show remarkable similarity in overall structure, it is increasingly apparent that there is enormous diversity in the redox partner systems that drive the P450 enzymes. This paper examines some of the recent advances in our understanding of the biodiversity of the P450 redox apparatus, with a particular emphasis on the redox systems in the pathogen Mycobacterium tuberculosis.
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August 2005
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Conference Article|
August 01 2005
Biodiversity of cytochrome P450 redox systems
K.J. McLean;
K.J. McLean
1
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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M. Sabri;
M. Sabri
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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K.R. Marshall;
K.R. Marshall
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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R.J. Lawson;
R.J. Lawson
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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D.G. Lewis;
D.G. Lewis
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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D. Clift;
D. Clift
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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P.R. Balding;
P.R. Balding
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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A.J. Dunford;
A.J. Dunford
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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A.J. Warman;
A.J. Warman
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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J.P. McVey;
J.P. McVey
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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A.-M. Quinn;
A.-M. Quinn
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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M.J. Sutcliffe;
M.J. Sutcliffe
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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N.S. Scrutton;
N.S. Scrutton
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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A.W. Munro
A.W. Munro
1
1Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, U.K.
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Publisher: Portland Press Ltd
Received:
April 13 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 796–801.
Article history
Received:
April 13 2005
Citation
K.J. McLean, M. Sabri, K.R. Marshall, R.J. Lawson, D.G. Lewis, D. Clift, P.R. Balding, A.J. Dunford, A.J. Warman, J.P. McVey, A.-M. Quinn, M.J. Sutcliffe, N.S. Scrutton, A.W. Munro; Biodiversity of cytochrome P450 redox systems. Biochem Soc Trans 1 August 2005; 33 (4): 796–801. doi: https://doi.org/10.1042/BST0330796
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