Integrins are crucial regulators of essential cellular processes such as gene expression, cell proliferation and migration. Alteration of these processes is central to tumourigenesis. Integrin signals mediate anchorage dependence of cell growth, while growth of cancer cells is anchorage-independent. Integrins critically regulate Rho family GTPases, that are also involved in cell-cycle progression and oncogenesis. In addition to their effect on GTP loading, integrins independently control the translocation of GTP-bound Rac to the plasma membrane. This step is essential for Rac binding to effectors. Integrins increase membrane affinity for Rac, leading to RhoGDI dissociation and effector coupling locally, in the vicinity of activated/bound integrins. Integrin-regulated Rac binding sites are within CEMMs (cholesterol-enriched membrane microdomains). Integrins control Rac signalling by preventing the internalization of its binding sites in CEMMs. Integrin regulation of signalling pathways initiated in CEMMs may be important for the spatial control of cell migration and anchorage dependence of cell growth.
Skip Nav Destination
Article navigation
August 2005
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
August 01 2005
Integrin regulation of membrane domain trafficking and Rac targeting
A. Grande-García;
A. Grande-García
1
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Ronda de Poniente, 5, 28760 Tres Cantos, Madrid, Spain
Search for other works by this author on:
A. Echarri;
A. Echarri
1
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Ronda de Poniente, 5, 28760 Tres Cantos, Madrid, Spain
Search for other works by this author on:
M.A. Del Pozo
M.A. Del Pozo
2
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Ronda de Poniente, 5, 28760 Tres Cantos, Madrid, Spain
2To whom correspondence should be addressed (email madelpozo@cnic.es).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
February 22 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 609–613.
Article history
Received:
February 22 2005
Citation
A. Grande-García, A. Echarri, M.A. Del Pozo; Integrin regulation of membrane domain trafficking and Rac targeting. Biochem Soc Trans 1 August 2005; 33 (4): 609–613. doi: https://doi.org/10.1042/BST0330609
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.