The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.

Keywords:
gene expression, ribonucleoprotein (RNP), herpes simplex virus, ICP27, nuclear export, pre-mRNA splicing
© 2005 The Biochemical Society
2005
You do not currently have access to this content.