L-selectin is constitutively expressed on the surface of most leucocytes and is important for tethering and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs (e.g. naive T cells) and sites of inflammation (e.g. neutrophils). Previous studies have shown that the 17-amino-acid L-selectin cytoplasmic tail is important for its function in cell adhesion and, hence, identifying binding partners will provide insight into how L-selectin is regulated in leucocytes. This review describes currently known binding partners of the L-selectin tail and how their associations affect L-selectin function.
Skip Nav Destination
Conference Article| October 26 2004
The telling tail of L-selectin
*Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, U.K.
†Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, U.K.
Search for other works by this author on:
- Views Icon Views
- Share Icon Share
A. Ivetic, A.J. Ridley; The telling tail of L-selectin. Biochem Soc Trans 1 November 2004; 32 (6): 1118–1121. doi: https://doi.org/10.1042/BST0321118
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article