Transcription by RNA polymerase II requires the assembly of the general transcription factors at the promoter to form a preinitiaiton complex. TFIIB (transcription factor IIB) plays a central role in this process, mediating the recruitment of RNA polymerase II and positioning it over the transcription start site. The assembly of TFIIB at the promoter can be a limiting event and several activator proteins have been shown to target TFIIB recruitment in the process of transcriptional stimulation. TFIIB is composed of two domains that engage in an intramolecular interaction. Indeed, the conformation of TFIIB has been found to underpin the function of this general transcription factor. Here we discuss our current understanding of TFIIB conformation and its role in transcription control.
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November 2004
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Conference Article|
October 26 2004
The role of TFIIB conformation in transcriptional regulation
L.M. Elsby;
L.M. Elsby
1School of Biological Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
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S.G.E. Roberts
S.G.E. Roberts
1
1School of Biological Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (email stefan.roberts@man.ac.uk).
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Biochem Soc Trans (2004) 32 (6): 1098–1099.
Article history
Received:
July 23 2004
Citation
L.M. Elsby, S.G.E. Roberts; The role of TFIIB conformation in transcriptional regulation. Biochem Soc Trans 1 November 2004; 32 (6): 1098–1099. doi: https://doi.org/10.1042/BST0321098
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