The inhibitors of oxidative phosphorylation induced fragmentation of mitochondria without any signs of apoptosis in CV-1 and HeLa cells. Prolonged treatment with the uncouplers (alone or in combination with the inhibitors of respiration) caused perinuclear clusterization of mitochondria, followed by their selective elimination. The fraction of mitochondria-depleted cells remained viable.
Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions
K.G. Lyamzaev, O.Y. Pletjushkina, V.B. Saprunova, L.E. Bakeeva, B.V. Chernyak, V.P. Skulachev; Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions. Biochem Soc Trans 1 November 2004; 32 (6): 1070–1071. doi: https://doi.org/10.1042/BST0321070
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