PH domains (pleckstrin homology domains) are the 11th most common domain in the human genome and are best known for their ability to target cellular membranes by binding specifically to phosphoinositides. Recent studies in yeast have shown that, in fact, this is a property of only a small fraction of the known PH domains. Most PH domains are not capable of independent membrane targeting, and those capable of doing so (approx. 33%) appear, most often, to require both phosphoinositide and non-phosphoinositide determinants for their subcellular localization. Several recent studies have suggested that small GTPases such as ARF family proteins play a role in defining PH domain localization. Some others have described a signalling role for PH domains in regulating small GTPases, although phosphoinositides may also play a role. These findings herald a change in our perspective of PH domain function, which will be significantly more diverse than previously supposed.
Skip Nav Destination
Article navigation
November 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 26 2004
Pleckstrin homology domains: not just for phosphoinositides
M.A. Lemmon
M.A. Lemmon
1
1Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6059, U.S.A.
1email mlemmon@mail.med.upenn.edu
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 23 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 707–711.
Article history
Received:
July 23 2004
Citation
M.A. Lemmon; Pleckstrin homology domains: not just for phosphoinositides. Biochem Soc Trans 1 November 2004; 32 (5): 707–711. doi: https://doi.org/10.1042/BST0320707
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.