Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neutrophils gradually lose the anti-apoptotic protein Mcl-1 and Bax translocates and inserts into the mitochondrial membrane. However, other reports show that caspase 8 is required for neutrophil apoptosis, suggesting the involvement of DR (death receptor) signalling. As DR ligation is not required for neutrophil apoptosis, this raises the intriguing possibility that activation of caspase 8 during neutrophil apoptosis occurs via a novel mechanism. In the present paper, we discuss the current evidence for mechanisms occurring in neutrophil apoptosis, which could trigger DR signalling in the absence of DR ligation.
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Conference Article|
June 01 2004
Early events in spontaneous neutrophil apoptosis
D. Scheel-Toellner;
D. Scheel-Toellner
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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K.-Q. Wang;
K.-Q. Wang
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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P.R. Webb;
P.R. Webb
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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S.H. Wong;
S.H. Wong
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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R. Craddock;
R. Craddock
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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L.K. Assi;
L.K. Assi
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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M. Salmon;
M. Salmon
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
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J.M. Lord
J.M. Lord
1
MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email J.M.Lord@bham.ac.uk).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (3): 461–464.
Citation
D. Scheel-Toellner, K.-Q. Wang, P.R. Webb, S.H. Wong, R. Craddock, L.K. Assi, M. Salmon, J.M. Lord; Early events in spontaneous neutrophil apoptosis. Biochem Soc Trans 1 June 2004; 32 (3): 461–464. doi: https://doi.org/10.1042/bst0320461
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