Each of the sequenced Sulfolobus genomes contains large numbers of putatively mobile elements, both IS elements (insertion sequence elements) and MITEs (miniature inverted-repeat transposable elements). There are 344 in the 3.0 Mb genome of Sulfolobus solfataricus P2 and 95 in the 2.7 Mb genome of Sulfolobus tokodaii. In the former they constitute more than 10% of the genome. Experimental data suggest that transposition of IS elements occurs frequently. Moreover, the gene order between the two organisms differs greatly, indicating that multiple rearrangements have occurred. This has also led to considerable speculation as to how the cells are viable. Recently, a third Sulfolobus genome was completed which contains no IS elements or MITEs. This enabled us to compare the gene orders of the three genomes and provide evidence for mobile element-induced rearrangements of sections of the genomes.
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April 2004
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Conference Article|
April 01 2004
Shuffling of Sulfolobus genomes by autonomous and non-autonomous mobile elements
K. Brügger;
K. Brügger
Danish Archaea Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83, 1307-Copenhagen K, Denmark
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E. Torarinsson;
E. Torarinsson
Danish Archaea Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83, 1307-Copenhagen K, Denmark
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P. Redder;
P. Redder
Danish Archaea Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83, 1307-Copenhagen K, Denmark
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L. Chen;
L. Chen
Danish Archaea Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83, 1307-Copenhagen K, Denmark
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R.A. Garrett
R.A. Garrett
1
Danish Archaea Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83, 1307-Copenhagen K, Denmark
1To whom correspondence should be addressed (e-mail garrett@mermaid.molbio.ku.dk).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (2): 179–183.
Citation
K. Brügger, E. Torarinsson, P. Redder, L. Chen, R.A. Garrett; Shuffling of Sulfolobus genomes by autonomous and non-autonomous mobile elements. Biochem Soc Trans 1 April 2004; 32 (2): 179–183. doi: https://doi.org/10.1042/bst0320179
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