The PPARs (peroxisome-proliferator-activated receptors) α, β/ δ and γ belong to the nuclear hormone receptor superfamily. While all three receptors are undetectable in adult mouse interfollicular epidermis, PPARβ expression and activity is strongly re-activated by inflammatory stimuli during epidermal injury. The pro-inflammatory cytokine TNFα (tumour necrosis factor α) stimulates transcription of the PPARβ gene via an activator protein-1 site in its promoter and it also triggers the production of PPARβ ligands in keratinocytes. This increase of PPARβ activity in these cells up-regulates the expression of integrin-linked kinase and 3-phosphoinositide-dependent kinase-1, which phosphorylates protein kinase B-α (Akt1). The resulting increase in Akt1 activity suppresses apoptosis and ensures the presence of a sufficient number of viable keratinocytes at the wound margin for re-epithelialization. Together, these observations reveal that PPARβ takes on multiple roles and contributes favourably to the process of wound closure.
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Conference Article|
February 01 2004
Critical roles of the nuclear receptor PPARβ (peroxisome-proliferator-activated receptor β) in skin wound healing
N.S. Tan;
N.S. Tan
Centre Intégratif de Génomique, Université de Lausanne, Bâtiment de biologie, CH-1015 Lausanne, Switzerland
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L. Michalik;
L. Michalik
Centre Intégratif de Génomique, Université de Lausanne, Bâtiment de biologie, CH-1015 Lausanne, Switzerland
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N. Di-Poï;
N. Di-Poï
Centre Intégratif de Génomique, Université de Lausanne, Bâtiment de biologie, CH-1015 Lausanne, Switzerland
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B. Desvergne;
B. Desvergne
Centre Intégratif de Génomique, Université de Lausanne, Bâtiment de biologie, CH-1015 Lausanne, Switzerland
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W. Wahli
W. Wahli
1
Centre Intégratif de Génomique, Université de Lausanne, Bâtiment de biologie, CH-1015 Lausanne, Switzerland
1To whom correspondence should be addressed (e-mail walter.wahli@cig.unil.ch).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 97–102.
Citation
N.S. Tan, L. Michalik, N. Di-Poï, B. Desvergne, W. Wahli; Critical roles of the nuclear receptor PPARβ (peroxisome-proliferator-activated receptor β) in skin wound healing. Biochem Soc Trans 1 February 2004; 32 (1): 97–102. doi: https://doi.org/10.1042/bst0320097
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