A single gene encoding a δ6-desaturase (FADS2) has been isolated and characterized in mammalian species. This δ6-desaturase plays a major role in the biosynthesis of PUFAs (polyunsaturated fatty acids). It catalyses the rate-limiting desaturation of linoleic acid (C18:2n−6) and α-linolenic acid (C18:3n−3) required for the biosynthesis of long-chain PUFAs. Moreover, recent studies have provided strong evidence that this δ6-desaturase also acts on 24-carbon PUFAs of both the n−6 and n−3 series. Another substrate of this δ6-desaturase has been identified through complementary works from different investigators. This δ6-desaturase acts on a saturated fatty acid, palmitic acid (C16:0), leading to the newly characterized biosynthesis of hexadecenoic acid (C16:1n−10) or sapienate.
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Conference Article|
February 01 2004
The surprising diversity of Δ6-desaturase substrates
H. Guillou;
H. Guillou
Laboratoire de Biochimie, INRA-ENSA, 65 rue de Saint-Brieuc, CS84215, 35042 Rennes cedex, France
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S. D'Andrea;
S. D'Andrea
Laboratoire de Biochimie, INRA-ENSA, 65 rue de Saint-Brieuc, CS84215, 35042 Rennes cedex, France
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V. Rioux;
V. Rioux
Laboratoire de Biochimie, INRA-ENSA, 65 rue de Saint-Brieuc, CS84215, 35042 Rennes cedex, France
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S. Jan;
S. Jan
Laboratoire de Biochimie, INRA-ENSA, 65 rue de Saint-Brieuc, CS84215, 35042 Rennes cedex, France
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P. Legrand
P. Legrand
1
Laboratoire de Biochimie, INRA-ENSA, 65 rue de Saint-Brieuc, CS84215, 35042 Rennes cedex, France
1To whom correspondence should be addressed (e-mail Philippe.Legrand@agrorennes.educagri.fr).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 86–87.
Citation
H. Guillou, S. D'Andrea, V. Rioux, S. Jan, P. Legrand; The surprising diversity of Δ6-desaturase substrates. Biochem Soc Trans 1 February 2004; 32 (1): 86–87. doi: https://doi.org/10.1042/bst0320086
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