Dietary fat provides a major source of nutrition, but may in excess lead to obesity, insulin resistance, high blood cholesterol levels and atherosclerosis. Here we report molecular events that co-ordinate whole-body lipid homoeostasis from insects to humans, viewed in the context of rare and common genetic disorders of apolipoprotein B-containing lipoprotein production.

Keywords:
abetalipoproteinaemia, Anderson disease, chylomicron-retention disease, familial combined hyperlipidaemia, microsomal triacylglycerol transfer protein
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© 2004 Biochemical Society
2004
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