Biochemical, biophysical and biological studies of oligonucleotides containing lesions at defined sites provide a molecular basis for the effects of DNA lesions. dG (deoxyguanosine) is the most easily oxidized of the four native nucleotides. The chemical reactivity of dG correlates with compilations of mutations, which reveal that a significant fraction of transitions or transversions involve dG. OxodG (7,8-dihydro-8-hydroxy-2´-deoxyguanosine) is widely recognized as an important lesion derived from the oxidation of dG, and significant effort has been expended in studies of its effects on DNA structure and function. Recently, the properties of other lesions derived from dG and/or the oxidation of OxodG have been uncovered. Studies on these lesions reveal that they too are biologically significant.
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Conference Article|
February 01 2004
In vitro and in vivo effects of oxidative damage to deoxyguanosine
M.M. Greenberg
M.M. Greenberg
1
Department of Chemistry, Johns Hopkins University, 3400 North Charles St, Baltimore, MD 21218, U.S.A.
1e-mail mgreenberg@jhu.edu
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 46–50.
Citation
M.M. Greenberg; In vitro and in vivo effects of oxidative damage to deoxyguanosine. Biochem Soc Trans 1 February 2004; 32 (1): 46–50. doi: https://doi.org/10.1042/bst0320046
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