Fatty acid–bile acid conjugates (FABACs) were shown recently to have important and multiple effects on cholesterol metabolism. In human fibroblasts, they were found to markedly enhance cholesterol efflux by an ATP-binding cassette transporter A1-dependent pathway. In C57L/J mice, they increased CYP7A1 activity and RNA expression, while decreasing moderately 3-hydroxy-3-methylglutaryl-CoA reductase activity. In C57L/J mice and in hamsters, they also decreased serum cholesterol levels, whereas in other animals, this effect was not seen in short-term experiments. In the present study, we investigated potential mechanisms of action of arachidyl amido cholanoic acid (Aramchol), with particular reference to biliary and faecal sterol outputs in rats. Supplementation with Aramchol at a dose of 150 mg·kg−1·day−1 increased neutral sterol output by approx. 50%, while the faecal outputs of bile salts and total sterols increased by almost 2-fold. Biliary lipid outputs were not significantly different between the control and FABAC-supplemented animals. These findings indicate an overall catabolic effect of FABACs on body cholesterol.
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Conference Article|
February 01 2004
Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats
A. Leikin-Frenkel;
A. Leikin-Frenkel
1
*Minerva Center for Cholesterol, Gallstones and Lipid Metabolism in the Liver, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
1To whom correspondence should be addressed (e-mail alicial@post.tau.ac.il).
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A.A Weinbroum;
A.A Weinbroum
†Animal Research Laboratory, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
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D. Leikin-Gobbi;
D. Leikin-Gobbi
†Animal Research Laboratory, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
§Galmed Medical Research Ltd, 8 Shaul HaMelech Boulevard, Tel Aviv 64733, Israel
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L. Krupitzky;
L. Krupitzky
†Animal Research Laboratory, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
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I. Goldiner;
I. Goldiner
‡Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
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L. Shafat;
L. Shafat
*Minerva Center for Cholesterol, Gallstones and Lipid Metabolism in the Liver, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
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T. Gilat;
T. Gilat
‡Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
§Galmed Medical Research Ltd, 8 Shaul HaMelech Boulevard, Tel Aviv 64733, Israel
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F.M. Konikoff
F.M. Konikoff
*Minerva Center for Cholesterol, Gallstones and Lipid Metabolism in the Liver, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
‡Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 131–133.
Citation
A. Leikin-Frenkel, A.A Weinbroum, D. Leikin-Gobbi, L. Krupitzky, I. Goldiner, L. Shafat, T. Gilat, F.M. Konikoff; Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats. Biochem Soc Trans 1 February 2004; 32 (1): 131–133. doi: https://doi.org/10.1042/bst0320131
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