The scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that can mediate the binding and bi-directional lipid transfer between high-density lipoproteins (HDLs) and cells. It is expressed in a variety of tissues, including the liver, and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels in mice. Mice lacking SR-BI exhibit impaired hepatic-selective HDL cholesterol uptake and increased atherosclerosis, suggesting that SR-BI is required for hepatic reverse cholesterol transport and normally protects against atherosclerosis. Surprisingly, elimination of SR-BI in apolipoprotein E knockout mice results in rapid development of occlusive coronary artery disease, accompanied by spontaneous myocardial infarction, reduced heart function and early death, which points to a role for SR-BI in protection against coronary heart disease. The in vivo role of macrophage SR-BI has been less clear. We have used bone-marrow transplantation to demonstrate that bone-marrow-derived SR-BI also normally protects against atherosclerosis in low-density lipoprotein receptor knockout mice. These results suggest that SR-BI may have multiple protective effects against atherosclerosis in different tissues.
Skip Nav Destination
Article navigation
Conference Article|
February 01 2004
Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice
B. Trigatti;
B. Trigatti
1
Department of Biochemistry, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
1To whom correspondence should be addressed (e-mail trigatt@mcmaster.ca).
Search for other works by this author on:
S. Covey;
S. Covey
Department of Biochemistry, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
Search for other works by this author on:
A. Rizvi
A. Rizvi
Department of Biochemistry, McMaster University, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 116–120.
Citation
B. Trigatti, S. Covey, A. Rizvi; Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice. Biochem Soc Trans 1 February 2004; 32 (1): 116–120. doi: https://doi.org/10.1042/bst0320116
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.