There is general agreement that a systems approach is needed for a better understanding of causal and functional relationships that generate the dynamics of biological networks and pathways. These observations have been the basis for efforts to get the engineering and physical sciences involved in life sciences. The emergence of systems biology as a new area of research is evidence for these developments. Dynamic modelling and simulation of signal transduction pathways is an important theme in systems biology and is getting growing attention from researchers with an interest in the analysis of dynamic systems. This paper introduces systems biology in terms of the analysis and modelling of signal transduction pathways. Focusing on mathematical representations of cellular dynamics, a number of emerging challenges and perspectives are discussed.
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December 2003
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Conference Article|
December 01 2003
Analysis and modelling of signal transduction pathways in systems biology
K.-H. Cho;
K.-H. Cho
1
*School of Electrical Engineering, University of Ulsan, Ulsan, 680-749, South Korea
1To whom correspondence should be addressed (e-mail ckh@mail.ulsan.ac.kr).
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O. Wolkenhauer
O. Wolkenhauer
†Bioinformatics & Systems Biology Group, Department of Computer Science, University of Rostock, Albert Einstein Str. 21, 18051 Rostock, Germany
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (6): 1503–1509.
Citation
K.-H. Cho, O. Wolkenhauer; Analysis and modelling of signal transduction pathways in systems biology. Biochem Soc Trans 1 December 2003; 31 (6): 1503–1509. doi: https://doi.org/10.1042/bst0311503
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