A group of integral membrane proteins, known as C-tail anchored, is defined by the presence of a cytosolic N-terminal domain that is anchored to the phospholipid bilayer by a single segment of hydrophobic amino acids close to the C-terminus. The mode of insertion into membranes of these proteins, many of which play key roles in fundamental intracellular processes, is obligatorily post-translational, is highly specific and may be subject to regulatory processes that modulate the protein's function. Recent work has demonstrated that tail-anchored proteins translocate their C-termini across the endoplasmic reticulum membrane by a mechanism different from that used for Sec61-dependent post-translational signal-peptide-driven translocation. Here we summarize recent results on the insertion of tail-anchored proteins and discuss possible mechanisms that could be involved.
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December 2003
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Conference Article|
December 01 2003
Biogenesis of tail-anchored proteins
N. Borgese;
N. Borgese
1
*Consiglio Nazionale delle Ricerche Institute for Neuroscience, Cellular and Molecular Pharmacology Section, University of Milan, via Vanvitelli 32, 20129 Milano, Italy
†Faculty of Pharmacy, University of Catanzaro Magna Graecia, 88021 Roccelletta di Borgia (CZ), Italy
1To whom correspondence should be addressed (e-mail n.borgese@in.cnr.it).
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S. Brambillasca;
S. Brambillasca
*Consiglio Nazionale delle Ricerche Institute for Neuroscience, Cellular and Molecular Pharmacology Section, University of Milan, via Vanvitelli 32, 20129 Milano, Italy
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P. Soffientini;
P. Soffientini
*Consiglio Nazionale delle Ricerche Institute for Neuroscience, Cellular and Molecular Pharmacology Section, University of Milan, via Vanvitelli 32, 20129 Milano, Italy
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M. Yabal;
M. Yabal
‡Program of Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
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M. Makarow
M. Makarow
‡Program of Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
§Department of Applied Chemistry and Microbiology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (6): 1238–1242.
Citation
N. Borgese, S. Brambillasca, P. Soffientini, M. Yabal, M. Makarow; Biogenesis of tail-anchored proteins. Biochem Soc Trans 1 December 2003; 31 (6): 1238–1242. doi: https://doi.org/10.1042/bst0311238
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